Drug Information for TRIAMTERENE/HYDROCHLOROTHIAZIDECAPSULES, USP37.5 MG/25 MG (BARR LABORATORIES, INC.): Overdosage

Electrolyte imbalance is the major concern (see WARNINGS section).

Symptoms reported include: polyuria, nausea, vomiting, weakness, lassitude, fever, flushed face and hyperactive deep tendon reflexes. If hypotension occurs, it may be treated with pressor agents such as levarterenol to maintain blood pressure. Carefully evaluate the electrolyte pattern and fluid balance. Induce immediate evacuation of the stomach through emesis or gastric lavage. There is no specific antidote.

Reversible acute renal failure following ingestion of 50 tablets of a product containing a combination of 50 mg triamterene and 25 mg hydrochlorothiazide has been reported.

Although triamterene is largely proteinbound (approximately 67%), there may be some benefit to dialysis in cases of overdosage.