Drug Information for TRIAMTERENE/HYDROCHLOROTHIAZIDECAPSULES, USP37.5 MG/25 MG (BARR LABORATORIES, INC.): ADVERSE REACTIONS

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  • Adverse effects are listed in decreasing order of frequency; however, the most serious adverse effects are listed first regardless of frequency. The serious adverse effects associated with triamterene/hydrochlorothiazide capsules have commonly occurred in less than 0.1% of patients treated with this product.

  • Hypersensitivity:

  • anaphylaxis, rash, urticaria, photosensitivity.

  • Cardiovascular:

  • arrhythmia, postural hypotension.

  • Metabolic:

  • diabetes mellitus, hyperkalemia, hyperglycemia, glycosuria, hyperuricemia, hypokalemia, hyponatremia, acidosis, hypochloremia.

  • Gastrointestinal:

  • jaundice and/or liver enzyme abnormalities, pancreatitis, nausea and vomiting, diarrhea, constipation, abdominal pain.

  • Renal:

  • acute renal failure (one case of irreversible renal failure has been reported), interstitial nephritis, renal stones composed primarily of triamterene, elevated BUN and serum creatinine, abnormal urinary sediment.

  • Hematologic:

  • leukopenia, thrombocytopenia and purpura, megaloblastic anemia.

  • Musculoskeletal:

  • muscle cramps.

  • Central Nervous System:

  • weakness, fatigue, dizziness, headache, dry mouth.

  • Miscellaneous:

  • impotence, sialadenitis. Thiazides alone have been shown to cause the following additional adverse reactions:

  • Central Nervous System:

  • paresthesias, vertigo.

  • Ophthalmic:

  • xanthopsia, transient blurred vision.

  • Respiratory:

  • allergic pneumonitis, pulmonary edema, respiratory distress.

  • Other:

  • necrotizing vasculitis, exacerbation of lupus.

  • Hematologic:

  • aplastic anemia, agranulocytosis, hemolytic anemia.

  • Neonate and infancy:

  • thrombocytopenia and pancreatitis — rarely, in newborns whose mothers have received thiazides during pregnancy.

  • Drug Information Provided by National Library of Medicine (NLM).
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