Drug Information for OXYCODONE AND ACETAMINOPHEN Tablets, USP (American Health Packaging): DOSAGE AND ADMINISTRATION

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  • Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. Oxycodone and acetaminophen tablets are given orally. The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.

    Strength Maximal Daily Dose

    Oxycodone and Acetaminophen Tablets 5 mg / 325 mg 12 Tablets

    Cessation of Therapy

    In patients treated with oxycodone and acetaminophen tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.

  • Drug Information Provided by National Library of Medicine (NLM).
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