Drug Information for GLIPIZIDE TABLETS USPFor Oral UseRx only (Ivax Pharmaceuticals, Inc.): DESCRIPTION

  • Glipizide tablets USP are oral blood-glucose-lowering drugs of the sulfonylurea class.

    The Chemical Abstracts name of glipizide is 1-cyclo-hexyl-3-[[p-[2-(5-methylpyrazine- carboxamido) ethyl]-phenyl]sulfonyl]urea. The molecular formula is C21H27N5O4S; the molecular weight is 445.55; the structural formula is shown below:

    Glipizide is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. Glipizide tablets for oral use are available in 5 and 10 mg strengths.

    Each tablet contains the following inactive ingredients: silicon dioxide; lactose monohydrate; microcrystalline cellulose; pregelatinized starch; stearic acid.

  • Drug Information Provided by National Library of Medicine (NLM).